منابع مشابه
Hormesis Is Biology, Not Religion
Should hormesis, as Thayer et al. (2006) implied in the title of their letter in the November 2006 issue of Environmental Health Perspectives, be dismissed by scientists, regulators, and others as simply a new faithbased religion? No. Hormesis is a data-based biological reality, one that challenges the lowdose assumptions that currently drive risk assessment processes used by regulatory and pub...
متن کاملHormesis: a fundamental concept in biology
This paper assesses the hormesis dose response concept, including its historical foundations, frequency, generality, quantitative features, mechanistic basis and biomedical, pharmaceutical and environmental health implications. The hormetic dose response is highly generalizable, being independent of biology model (i.e. common from plants to humans), level of biological organization (i.e. cell, ...
متن کاملHormesis is central to toxicology, pharmacology and risk assessment.
This paper summarizes numerous conceptual and experimental advances over the past two decades in the study of hormesis. Hormesis is now generally accepted as a real and reproducible biological phenomenon, being highly generalized and independent of biological model, endpoint measured and chemical class/physical stressor. The quantitative features of the hormetic dose response are generally high...
متن کاملHormesis: Principles and Applications for Pharmacology and Toxicology
The present assessment places hormetic dose responses within an historical context, documenting its origin, rejection by the biomedical community during the early decades of the 20 due to its close association with homeopathy and its revitalization during the later decades of the past century as the biomedical and toxicological communities became very interested in low dose effects of drugs and...
متن کاملSystems biology and pharmacology.
Drug action depends not only on the direct consequences of the interaction between the drug and its target but also on other consequences within the complex physiological system that is the human body. The National Institute of General Medical Sciences (NIGMS) has brought together investigators from the emerging field of systems biology with pharmacologists to explore possible avenues for utili...
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ژورنال
عنوان ژورنال: Biochemistry & Pharmacology: Open Access
سال: 2014
ISSN: 2167-0501
DOI: 10.4172/2167-0501.1000e149